Image

11:35 PM / Thursday September 29, 2022

5 Jul 2011

Researchers analyze gene changes in

  • Facebook
  • Twitter
July 5, 2011 Category: Health Posted by:

By Alicia Chang

associated press

 

Image

LOS ANGELES — Researchers analyzing the genetic makeup of ovarian cancer tumors have found a gene mutation that is surprisingly frequent, suggesting it plays a key role in driving the cancer.

 

The finding, appearing in Thursday’s issue of the journal Nature, may eventually lead to tests for earlier diagnosis of the disease and to better treatment. Ovarian cancer kills nearly 14,000 women in the United States each year. It’s usually not spotted until at an advanced stage.

 

The gene sequencing was carried out by The Cancer Genome Atlas, a federally funded network of medical centers that analyzed 316 ovarian tumors.

 

Scientists found that 96 percent of the tumors had mutated TP53 genes. The mutations were not present in normal tissue from the patients, showing they arose within the tumors. Normally, the gene directs the cell how to make a protein that acts as a tumor suppressor, keeping cells from growing and dividing uncontrollably.

 

Alterations in nine other genes also played a role in ovarian cancer, though to a much lesser extent, the researchers reported. Among them were the BRCA1 and BRCA2 genes, which increase the risk of breast and ovarian cancer.

 

“In other cancers, there are usually several genes that are involved” on almost equal footing, said one of the study authors, Dr. David Wheeler of Baylor College of Medicine. “This is an unusual pattern.”

 

The new work “is producing impressive insights into the biology” of ovarian cancer, Dr. Francis Collins, who heads the National Institutes of Health, said in a statement.

 

Among cancers, ovarian is the fifth leading cause of death among women. A regular pelvic exam is considered the best way to detect ovarian cancer early.

 

The Cancer Genome Atlas was launched in 2006 to unravel the genetic underpinning of cancer. The group mapped the genome of the most common form of brain cancer in 2008 and plans to do the same for 20 other types of cancers.

  • Facebook
  • Twitter

Leave a Comment

Recent News

Stateside

Mail ballot fight persists in key states, sure to slow count

September 23, 2022

Tweet Share Pin Email ABOVE PHOTO: Processed mail-in ballots are seen at the Chester County Voter Services...

Health

Wolf administration recognizes Suicide Prevention Awareness Month

September 23, 2022

Tweet Share Pin Email HARRISBURG, Pa. — Leadership from multiple state agencies joined advocates from Prevent Suicide...

Seniors

Art program helps people living with dementia

September 23, 2022

Tweet Share Pin Email ABOVE PHOTO: Sylvia M. paints a colorful pattern at an “ARTZ in the...

Color Of Money

EXPLAINER: How the strong U.S. dollar can affect everyone

September 23, 2022

Tweet Share Pin Email By Stan Choe ASSOCIATED PRESS  NEW YORK — The buck isn’t stopping. The...

Go With The-Flo

Roz Nixon visits with Lillias White to see her debut in the current Broadway hit “Hadestown”

September 23, 2022

Tweet Share Pin Email ABOVE PHOTO: Roz Nixon and Lillias White By Flo Anthony Curtis “50 Cent”...

Food And Beverage

What’s Cookin’? Roasted Curried Cauliflower

September 23, 2022

Tweet Share Pin Email Tweet Share Pin Email Related Posts What’s Cookin’? Garlic “Butter” Mushrooms and Cauliflower...

The Philadelphia Sunday Sun Staff